Energy Sources for Contraction of the Rat Ventricle in Phosphate Media
- 1 November 1955
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 3 (6), 559-563
- https://doi.org/10.1161/01.res.3.6.559
Abstract
Various substrates were tested for their ability to restore the amplitude of contraction of hypodynamic electrically-stimulated rat ventricle strips suspended in a phosphate-buffered medium. Greatest recovery of the contractile activity was obtained with pyruvate; lactate, β-hydroxybutyrate and acetate were more effective than succinate and glucose. The finding that glucose, in contrast to pyruvate, was relatively ineffective as an energy source for contraction, when a phosphate-buffered medium was employed, suggests that the defect was due to a rate-limiting step in the conversion of glucose to pyruvate, rather than to an impairment in the functioning of the Krebs cycle.Keywords
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