Development of the Primary Antibody Repertoire
- 20 November 1987
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 238 (4830), 1079-1087
- https://doi.org/10.1126/science.3317825
Abstract
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.Keywords
This publication has 140 references indexed in Scilit:
- Expression of immunoglobulin delta chain causes allelic exclusion in transgenic miceNature, 1987
- Developmental stage specificity of the lymphoid V(D)J recombination activity.Genes & Development, 1987
- A novel family of variable region genes of the human immunoglobulin heavy chainJournal of Molecular Biology, 1987
- Recombination between an expressed immunoglobulin heavy-chain gene and a germline variable gene segment in a Ly 1+ B-cell lymphomaNature, 1986
- Organization and evolution of variable region genes of the human immunoglobulin heavy chainJournal of Molecular Biology, 1986
- Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged Mu heavy chain geneCell, 1986
- Immunoglobulin genes in transgenic miceTrends in Genetics, 1985
- A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genesCell, 1985
- Chance, necessity and antibody gene dynamicsNature, 1983
- V–J joining of immunoglobulin κ genes only occurs on one homologous chromosomeNature, 1980