Chromosomes in old age: A six year longitudinal study
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 33 (1), 17-22
- https://doi.org/10.1007/bf00447282
Abstract
This first longitudinal study on aged subjects confirms previous cross-sectional observations of increasing aneuploidy with advancing age in women but not in men. In this study of 17 aged twins (mean age 89.7 years), 11 women and 6 men, spanning an interval of approximately 6 years between examinations, only women showed a significant increase in hypodiploidy (also hyperdiploidy and monosomy C). This increase in hypodiploidy was not due to a high frequency of chromosome loss in a few subjects but rather was exhibited by most of the subjects. While men showed a loss in G-group chromosomes during this 6-year interval, that loss was not statistically significant. These findings confirm for the first time by means of longitudinal follow-up that women and not men, even in the ninth decade of life, show a significant increase in hypodiploidy.This publication has 19 references indexed in Scilit:
- Survival of octogenarians: Six years after initial chromosome examinationExperimental Aging Research, 1976
- Chromosome Examinations in Aging Institutionalized WomenJournal of Gerontology, 1974
- THE MISSING Y CHROMOSOME AND HUMAN LEUKÆMIAThe Lancet, 1973
- Giemsa banding patterns of human chromosomes*Clinical Genetics, 1972
- The regulation of protein synthesis in the ageing cellExperimental Gerontology, 1970
- Chromosome Loss compared with Chromosome Size, Age and Sex of SubjectsNature, 1970
- Chromosomal Altertions in Three Age Groups of Human FemalesThe American Journal of the Medical Sciences, 1969
- Variation in the Human Chromosome NumberNature, 1967
- Chromosome Investigations of a Small Isolated Human Population: Chromosome Abnormalities and Distribution of Chromosome Counts According to Age and Sex Among the Population of Tristan Da CunhaNature, 1965
- Distribution of Human Chromosome Counts in Relation to AgeNature, 1961