An early haematopoietic defect in mice lacking the transcription factor GATA-2
- 15 September 1994
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 371 (6494), 221-226
- https://doi.org/10.1038/371221a0
Abstract
Blood cell development relies on the expansion and maintenance of haematopoietic stem and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we demonstrate that the transcription factor GATA-2 plays a critical role in haematopoiesis, particularly of an adult type. We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells.Keywords
This publication has 36 references indexed in Scilit:
- Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.Genes & Development, 1994
- An early pre-liver intraembryonic source of CFU-S in the developing mouseNature, 1993
- Para-aortic splanchnopleura from early mouse embryos contains B1a cell progenitorsNature, 1993
- GATA-binding transcription factors in hematopoietic cellsBlood, 1992
- Rescue of erythroid development in gene targeted GATA–1− mouse embryonic stem cellsNature Genetics, 1992
- Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1Nature, 1991
- Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.Genes & Development, 1990
- The erythroid-specific transcription factor eryf1: A new finger proteinCell, 1989
- Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cellsNature, 1989
- Ontogeny of the Haemopoietic System: Yolk Sac Origin of In Vivo and In Vitro Colony Forming Cells in the Developing Mouse Embryo*British Journal of Haematology, 1970