Mechanisms underlying induction and maintenance of long‐term potentiation in the hippocampus
- 1 February 1989
- Vol. 10 (2-3), 85-90
- https://doi.org/10.1002/bies.950100212
Abstract
Long‐term potentiation (LTP) in the hippocampus is accompanied by a number of changes on both sides of the synapse. It is now generally considered that the trigger for initiating LTP is the entry of calcium into the postsynaptic area through the NMDA‐associated channel while the mechanism(s) underlying the maintenance of LTP are less well understood and probably involve contributions from both sides of the synapse.Keywords
This publication has 40 references indexed in Scilit:
- Increased hydrolysis of phosphatidylinositol-4,5-bisphosphate in long-term potentiationNeuroscience Letters, 1988
- Phorbol ester-induced synaptic potentiation differs from long-term potentiation in the guinea pig hippocampus in vitroNeuroscience Letters, 1988
- Induction of Synaptic Potentiation in Hippocampus by Patterned Stimulation Involves Two EventsScience, 1986
- Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5Nature, 1986
- Two components of long-term potentiation in mossy fiber-induced excitation in hippocampusExperimental Neurology, 1985
- Selective increase in phosphorylation of a 47-kDa protein (F1) directly related to long-term potentiationBehavioral and Neural Biology, 1985
- Inositol trisphosphate, a novel second messenger in cellular signal transductionNature, 1984
- Long-lasting potentiation in hippocampus is not due to an increase in glutamate receptorsLife Sciences, 1984
- Magnesium gates glutamate-activated channels in mouse central neuronesNature, 1984
- Long-lasting morphological changes in dendritic spines of dentate granular cells following stimulation of the entorhinal areaJournal of Neurocytology, 1977