Maternal serum free beta hCG screening: Results of studies including 480 cases of down syndrome
- 1 February 1994
- journal article
- Published by Wiley in Prenatal Diagnosis
- Vol. 14 (2), 97-103
- https://doi.org/10.1002/pd.1970140204
Abstract
The median maternal serum free beta human chorionic gonadotropin (hCG) multiple of the median (MOM) of 480 Down syndrome cases in the second trimester was 2·64, significantly greater than the reported median MOM of intact hCG (p<0·0001). In 234 of these cases from retrospective and prospective studies, the effectiveness of maternal serum free beta hCG was evaluated in combination with alpha‐fetoprotein (AFP) and maternal age in second‐trimester Down syndrome screening. Down syndrome detection in the gestational age range of 14–16 weeks was 82 per cent. In all gestational weeks (14–22), a 77·7 per cent Down syndrome detection rate was achieved. In prospective screening of 44 272 patients under the age of 35 years, 69 per cent of Down syndrome cases were detected (73 per cent in gestational weeks 14–16). The false‐positive rate for the prospective study was 3·8 per cent. The use of free beta hCG combined with maternal serum AFP and maternal age‐related risk for Down syndrome in a screening population (i.e., women under 35 years) yields an improved detection efficiency over other protocols.Keywords
This publication has 16 references indexed in Scilit:
- Free β-Chorionic Gonadotropin: A Cross-Reactivity Study of Two Immunometric Assays Used in Prenatal Maternal Serum Screening for Down's SyndromeAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1993
- Free Beta Human Choriogonadotropin in Down's Syndrome Screening: A Multicentre Study of its Role Compared with other Biochemical MarkersAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1992
- Prenatal Screening for Down's Syndrome with Use of Maternal Serum MarkersNew England Journal of Medicine, 1992
- Dual Analyte Immunoassay—a New Approach to Neural Tube Defect and Down's Syndrome ScreeningAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1992
- Early Detection of Down's Syndrome Using Free Beta Human ChoriogonadotropinAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1992
- Maternal serum Down syndrome screening: Free β-protein is a more effective marker than human chorionic gonadotropinAmerican Journal of Obstetrics and Gynecology, 1990
- Maternal serum markers in screening for Down syndromeClinical Genetics, 1990
- Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalitiesPrenatal Diagnosis, 1987
- Critical issues in prenatal maternal serum α-fetoprotein screening for genetic anomaliesAmerican Journal of Obstetrics and Gynecology, 1986
- An association between low maternal serum α-fetoprotein and fetal chromosomal abnormalitiesAmerican Journal of Obstetrics and Gynecology, 1984