Anti-inflammatory and PG inhibitory effects of phenacetin and acetaminophen
- 1 December 1977
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 7 (5-6), 513-516
- https://doi.org/10.1007/bf02111123
Abstract
Although acetaminophen and phenacetin do not inhibit PG synthesis when added directly to isolated rat platelets and when given orally, both drugs inhibit carrageenan-induced hindpaw edema — a widely used inflammatory assay method. It does not appear that the anti-inflammatory effects of these non-steroidal drugs (unlike other well-known non-steroidal drugs) can be explained on the basis of PG-synthetase inhibition.This publication has 9 references indexed in Scilit:
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