CAROTID-OCCLUSION-PRESSOR REFLEX: INFLUENCE OF EXISTING MEAN ARTERIAL PRESSURE, OF ANESTHETICS AND OF GANGLIONIC- AND ADRENERGIC-BLOCKING DRUGS

Abstract

In dogs anesthetized with pentobarbital, urethane or ether the pressor response to bilateral occlusion of the carotid arteries (30 sec.) was found to be related directly to the pre-existing mean arterial pressure within the limits tested (70-160 mm. Hg). Tetraethylammonium chloride (5-15 mg./kg.), dihydroergocornine (DHO 180) (1-3 mg./kg.), or benzyl-bis-beta-chloroethylamine (2-4 mg./kg.) was shown to supprpss the response and alter the relationship of response to mean arterial pressure. Regression lines interpreting the carotid occlusion pressor response as a function of mean arterial pressure approach 0 response at 60 mm. Hg pressure. Minimum variability will be obtained if carotid-occlusion-pressor responses in future work are reported as change of mean arterial pressure due to occlusion x 100/initial mean arterial pressure less 60.