REGULATION OF ADENOSINE 3'=5'-MONOPHOSPHATE EFFLUX FROM ANIMAL-CELLS
- 1 January 1978
- journal article
- research article
- Vol. 253 (15), 5431-5436
Abstract
Cyclic[c]AMP efflux was measured following hormonal stimulation of adenylate cyclase in a variety of animal cells including C-6 rat glioma cells, WI-38 human fibroblasts and avian erythrocytes. Using a variety of inhibitors of mitochondrial function and glycolysis, a correlation was noted between cellular ATP levels and the rate of cAMP efflux in all cells examined. A relationship between the efflux rate and the magnitude of the membrane potential was not observed. Pharmacological agents which inhibited cAMP egress in these cells without reducing ATP levels included several prostaglandins (A > B > E > F) and probenecid. The characteristics of the cAMP efflux system resemble those of the organic anion transport system.This publication has 8 references indexed in Scilit:
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