Influence of LSD-25 on optically evoked potentials in the nonanesthetized rabbit

Abstract

The influence of LSD-25 (i.v.) upon the optically evoked cortical potentials was studied in chronically prepared unanesthetized and noncurarized rabbits over a 23-hour period. With moderate doses of the drug (35 µg/animal) the potentials were enhanced for a period of over 6 hours. The time course of the amplitudes indicates a triphasic pattern. LSD-25 reduced the latency of the potentials by about 10%. LSD-25 was found to have a marked effect upon variability of both the amplitude and the latency. Both these variabilities were greatly reduced for 1–3 hours after injection.