Der Einbau von Glucose-Kohlenstoff in die freien Aminosäuren des Mäusegehirns unter dem Einfluß von Pyritinol

Abstract

Thirty minutes after the intraperitoneal injection of [U-14C]glucose into mice, the majority of the radioactivity in the brain was in the free glutamic acid, which also had the highest specific activity of all the labelled compounds. From the comparatively low specific activity of the gamma-amino-butyric acid, it is concluded that this amino acid is not produced in a special metabolic compartment as was previously assumed. The total radioactivity in the brain after the injection of [14C]glucose was not increased by the chronic administration of the vitamin B6 derivative pyritinol (pyrithioxin; encephabol) and there was also no alteration in the concentration and radioactivity of the free amino acids in the mouse brain.