Effect of Hyperglycemia and Hypoglycemia on the Glycogen Content of the Pituitary and Adrenal Glands of Normal, Subdiabetic and Diabetic Rats
- 1 November 1962
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 71 (5), 745-751
- https://doi.org/10.1210/endo-71-5-745
Abstract
The glycogen content of pituitary, adrenal and thyroid tissue of alloxandiabetic and normal rats was determined. An increased glycogen content was found in these endocrine glands in the diabetic rats. The pituitary glycogen content appeared to reflect the blood sugar level. When the blood sugar of normal, subdiabetic and diabetic rats was elevated by massive injections of glucose, the pituitary glycogen content was increased moderately. When the blood sugar of diabetic rats was lowered by insulin injection, the pituitary glycogen content decreased; however, this change in glycogen content often lagged behind the blood sugar changes. By contrast, the adrenal glycogen content did not reflect the blood sugar level; when the blood sugar was decreased by insulin treatment (in the diabetic rat) or elevated by glucose administration (in both normal and diabetic rats), the adrenal glycogen content was decreased. The possible mechanisms by which hyper- and hypoglycemia affect the glycogen content of the endocrine glands are discussed.Keywords
This publication has 14 references indexed in Scilit:
- The Activation of Adrenal Phosphorylase by the Adrenocorticotropic HormoneJournal of Biological Chemistry, 1958
- Early Development of Glycogen Infiltration in Duct Epithelium of Dog Pancreas after Growth Hormone AdministrationExperimental Biology and Medicine, 1957
- LOSS OF ADRENAL GLYCOGEN IN THE RAT FOLLOWING STRESS OR TREATMENT WITH VARIOUS HORMONES12Endocrinology, 1955
- Alterations of Pancreas During Cortisone Diabetes in Rabbits.Experimental Biology and Medicine, 1955
- THE EFFECT OF THE HYPERGLYCEMIC FACTOR AND EPINEPHRINE ON ENZYME SYSTEMS OF LIVER AND MUSCLEAnnals of the New York Academy of Sciences, 1951
- GLYCOGEN INFILTRATION (SO-CALLED HYDROPIC DEGENERATION) IN THE PANCREAS IN HUMAN AND EXPERIMENTAL DIABETES MELLITUS1951
- THE EFFECT OF GLUCOSE ON THE ADRENAL RESPONSE TO ACTH IN HYPOPHYSECTOMIZED RATSEndocrinology, 1950
- CHANGES IN CIRCULATING EOSINOPHILES AND ADRENAL ASCORBIC ACID CONCENTRATION AFTER AGENTS ALTERING BLOOD SUGAR LEVELS AND AFTER SURGICAL CONDITIONSAmerican Journal of Physiology-Legacy Content, 1950
- EXPERIMENTAL DIABETES PRODUCED BY THE ADMINISTRATION OF GLUCOSEEndocrinology, 1948
- THE PRODUCTION AND COURSE OF ALLOXAN DIABETES IN THE RAT1946