The customary plans for full digitalization involve distribution of dosage in such a manner as to produce the full effects within two or three days. The period is frequently shortened by the use of larger doses. The average full dose of digitalis given at one time is rarely recommended except when the condition is desperate, the reason being that it is too large for the more sensitive patients and results in toxic symptoms. The extent of the variation from the average response to an average full dose would theoretically be reduced by a preparation of digitalis which would be more quickly and more regularly absorbed from the gastrointestinal tract. With such a preparation, single dose digitalization might prove to be a safe and satisfactory routine. Our experience with digitoxin1 during the past few years suggested that this material might be put to use in that way. It has long