Regio- and Enantioselective Cyclization of Epoxy Alcohols Catalyzed by a [CoIII(salen)] Complex

Publisher Website
Google Scholar
Abstract
The intramolecular cyclization of epoxy alcohols was catalyzed with excellent regio‐ and enantiocontrol by a [CoIII(salen)] complex. High endo selectivity was observed for the enantioselective cyclization of terminal epoxy alcohols [Eq. (a)], while the reaction of meso substrates produced novel cyclic and bicyclic ethers in good yields and high enantiopurity. TBME=tert‐butyl methyl ether.