Inhibition of Fibrinolysis by Hyperlipemia

Abstract

1. Parenteral injection of triton produced inhibition of fibrinolysis; this phenomenon correlated with hyperlipemia produced by the triton. 2. Triton induced hyperlipemia caused greater inhibition of fibrinolysis than did cholesterol feedings. It was suggested that this might be related to difference in cholesterol-phospholipid ratio. 3. Saturated fat emulsions produced a greater degree of fibrinolytic inhibition than did unsaturated fat preparations. ^* This work was supported by grant # C-3817 of the N. C. I. and # H-2867 of the N. I. H, and institutional funds. ^** Associate Professor Clinical Surgery, Cornell University Medical College; and Associate Member, Sloan-Kettering Inst. for Cancer Res. New York, N. Y. ^*** Assistant Resident, St. Vincent's Hospital, New York, N. Y.