Analysis of the Genetic Structure of Nontypeable Pneumococcal Strains Isolated from Conjunctiva
- 1 April 2005
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (4), 1694-1698
- https://doi.org/10.1128/jcm.43.4.1694-1698.2005
Abstract
More than 50% of the nontypeable (NT) pneumococcal strains received in our laboratory for reference purposes are isolated in sporadic cases of conjunctivitis. To determine the genetic structure of the population of these NT conjunctival strains, we analyzed 75 pneumococci (40 NT and 35 typeable) isolated from conjunctivas and 30 (15 NT and 15 typeable) isolated from other sources. The NT and typeable conjunctival strains grouped in separate clusters, whereas NT and typeable pneumococci isolated from other sources were similarly distributed. NT conjunctival strains belonged to two well-differentiated clonal lineages. The first, represented by three newly described sequence types, featured fully antibiotic susceptible strains and appeared to be characteristic of conjunctival tissue; the second, represented by the previously described ST344, had a pattern of multiresistance to penicillin, tetracycline, and erythromycin and shared a genetic background with some NT strains isolated from other sources.Keywords
This publication has 13 references indexed in Scilit:
- Confirmation of Nontypeable Streptococcus pneumoniae- Like Organisms Isolated from Outbreaks of Epidemic Conjunctivitis as Streptococcus pneumoniaeJournal of Clinical Microbiology, 2003
- An Outbreak of Conjunctivitis Due to AtypicalStreptococcus pneumoniaeNew England Journal of Medicine, 2003
- Evaluation of gene-technological and conventional methods in the identification of Streptococcus pneumoniaeJournal of Microbiological Methods, 2002
- A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive diseaseMicrobiology, 1998
- Application of molecular typing to the epidemiology of Streptococcus pneumoniae.Journal of Clinical Pathology, 1998
- Ambiguity in the Identification ofStreptococcus pneumoniae Optochin, Bile Solubility, Quellung, and the AccuProbe DNA Probe TestsAmerican Journal of Clinical Pathology, 1998
- Identifying non-capsulate strains of Streptococcus pneumoniae isolated from eyes.Journal of Clinical Pathology, 1986
- Pneumococcal Pneumonia and Septicemia Resulting from a Nontypable Strain of PneumococcusJournal of the American Geriatrics Society, 1985
- Etiology of acute conjunctivitis in childrenThe Journal of Pediatrics, 1981
- Epidemiology of Clinically Significant Isolates of Streptococcus pneumoniae in the United StatesClinical Infectious Diseases, 1981