The influence of insulin on the distribution of glycogen in normal animals

Abstract

The work of Goldblatt on the accumulation of glycogen in the liver of young fasting rabbits following injection of insulin was confirmed. The glycogen of the muscles is decreased about as much as the liver gains. Insulin caused no deposition of glycogen in the liver of the fasting chicken or mouse, but caused a definite increase of muscle glycogen in both cases. In the ferret, insulin had little effect on the liver glycogen, but caused formation of glycogen in the muscles. Very small amounts of adrenaline produced in the fasting rabbit a similar condition to that following injections of insulin.