Multiple sequence elements are required for regulation of human T-cell leukemia virus gene expression.
- 1 July 1987
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 84 (14), 4919-4923
- https://doi.org/10.1073/pnas.84.14.4919
Abstract
The U3 region of the long terminal repeat (LTR) of human T-cell leukemia virus type 1 (HTLV-I) contains sequences that respond to the trans-activating transcription (tat) factor encoded by the pX region of the provirus. Results presented here show that there are multiple tat-responsive sequences within the LTR and that a single 21-nucleotide sequence, which is repeated three times within the U3 region, is sufficient to determine the response to the trans-activator. This sequence is capable of conferring a tat-responsive phenotype upon the HTLV-1 and simian virus 40 promoters, independent of orientation. Sequences required for efficient HTLV-ILTR-directed gene expression are also located 3'' to the site of RNA initiation, within the R and U5 regions of the LTR.Keywords
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