Thromboplastic Activity of the Urine

Abstract

The clear protein and cell-free urine, spontaneously voided by normal cf d* and 9 ? or obtained by catheterization of the renal pelvis and bladder, has throm-boplastic activity when tested on normal and hemophilic blood. Urine from hemophilics has an activity not significantly different from that of normal [male][male]. The thrombo-plastic activity is retained in urine free of most of its solutes by dialysis against cold water for 48 hrs. The clean filtered dialyzed urine may be frozen and dried by the lyophil method; an avg. yield of 43.4 mgs. of residue/100 ml. of dialyzed urine is obtained. This residue has a clot accelerating action on hemophilic blood in vitro and in vivo, and a strong vaso depressor action when injected intravenously. The thrombo-plastin of the urine may come from one of the cellular or chemical components of the urine, the kidney itself, or may be cleared from the blood through the kidney, into the urine.