Effects of auranofin on leukotriene production and leukotriene stimulated neutrophil function
- 1 December 1984
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 15 (5-6), 551-555
- https://doi.org/10.1007/bf01966773
Abstract
Arachidonic acid is metabolized in neutrophils by lipoxygenase to leukotrienes, which are suggested to play a central role in inflammation. The antirheumatic drug auranofin (4 μg/ml) was found not to inhibit neutrophil production of the lipoxygenase products 5-HETE, 15-HETE and LTB4,in vitro when stimulated with the calcium ionophore A23187. Auranofin, however, modulated neutrophil aggregation, enzyme release and chemotaxis induced by LTB4. The results suggest that auranofin may exert some of its antirheumatic effects through affecting neutrophil responses to leukotrienes.This publication has 37 references indexed in Scilit:
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