Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2
Top Cited Papers
- 15 February 2008
- journal article
- Published by Springer Nature in EMBO Reports
- Vol. 9 (4), 377-383
- https://doi.org/10.1038/embor.2008.7
Abstract
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.Keywords
This publication has 23 references indexed in Scilit:
- Hierarchy of Notch–Delta interactions promoting T cell lineage commitment and maturationThe Journal of Experimental Medicine, 2007
- Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage DifferentiationToxicological Sciences, 2004
- Tissue‐specific and inducible Cre‐mediated recombination in the gut epitheliumGenesis, 2004
- Expression of Notch Receptors and Ligands in the Adult GutJournal of Histochemistry & Cytochemistry, 2004
- Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell DifferentiationJournal of Biological Chemistry, 2004
- Notch1 functions as a tumor suppressor in mouse skinNature Genetics, 2003
- Expression of Notch pathway components in fetal and adult mouse small intestineGene Expression Patterns, 2002
- The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer CellsCell, 2002
- Control of endodermal endocrine development by Hes-1Nature Genetics, 2000
- Translational Control of p27 Kip1 Accumulation During the Cell CycleScience, 1996