Experimental cerebral vasospasm after subarachnoid hemorrhage. Participation of adrenergic nerves in cerebral vessel wall.
- 1 November 1979
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 10 (6), 703-711
- https://doi.org/10.1161/01.str.10.6.703
Abstract
Distribution and morphology of nerves in basilar-artery-induced vasospasm were investigated electronmicroscopically. Small cored vesicles were transformed, decreased and disappeared gradually after development of vasospasm induced by blood-CSF mixture incubated 5--10 days. These changes were not induced by fresh arterial blood, lysed platelets in saline and mechanical stimulation. In the portion with severe vasospasm induced by incubated blood-CSF mixture, nerve distribution was rich and uniform in all portions of the adventitia. In the portion with slight vasospasm, nerves were extremely scanty in the innermost area of the adventitia, within 10 mu from the outer edge of the media. The severity of experimental vasospasm became definitely lighter and the duration shorter after bilateral cervical sympathectomy. These findings indicate that nerves, especially the adrenergic axon in the innermost area of the adventitia, may play an important role on the genesis of late vasospasm. The difference in nerve distribution may be a factor influencing individual differences in frequency or severity of vasospasm.This publication has 35 references indexed in Scilit:
- Etiology and Treatment of Prolonged VasospasmNeurologia medico-chirurgica, 1976
- Anatomical mapping of the cerebral nervi vasorum in the human brainJournal of Neurosurgery, 1975
- Prediction of Reattacks Following Rupture of Intracranial AneurysmsNeurologia medico-chirurgica, 1975
- Cervical Sympathectomy for Cerebral Vasospasm after Aneurysm RuptureNeurologia medico-chirurgica, 1975
- INNERVATION OF INTRACRANIAL ARTERIESBrain, 1970
- Experimental and Clinical Study of the Development of Spasm of the Cerebral Arteries Related to Subarachnoid HemorrhageJournal of Neurosurgery, 1970
- Licht- und elektronenmikroskopische Untersuchungen zur Innervation der PiagefäßeCell and tissue research, 1969
- Cerebral Arterial SpasmJournal of Neurosurgery, 1968
- Experimental Mechanical Arterial Stimulation at the Circle of WillisJournal of Neurosurgery, 1968
- Prevention of Serotonin-Produced Cerebral VasospasmJournal of Neurosurgery, 1963