Succinate Stimulation of Normal and Tumor Tissue Slice Metabolism Measured by Reduction of Tetrazolium Chloride.

Abstract

In studies with various human normal and cancer tissues and liver, kidney and spleen slices of control and tumor bearing mice, the per cent stimulation by succinate did not differ significantly in normal and tumor tissues. These findings were compared with previous studies of oxidative stim-ulation by succinate. It was also shown that the presence of a tumor did not change the endogenous or succinate stimulated dehydrogenase activity of the liver, kidney or spleen of mice as measured by the TTC technic.