Decreased synthesis of DNA in regenerating rat liver after the administration of reserpine

Abstract

1 Reserpine given to rats before the enhanced synthesis of DNA begins 14h after partial hepatectomy markedly depresses thymidine uptake into DNA at 24 hours. 2 At this time decreased activity of liver thymidine kinase but unchanged thymidine 5′-nucleotidase were observed. 3 Reserpine has no effect on DNA synthesis when administered simultaneously with the labelled thymidine 2 h before killing. 4 With depressed DNA synthesis after reserpine administration there is no significant decrease of liver RNA synthesis.