HISTOGENESIS OF SEBACEOUS GLAND CARCINOMAS PRODUCED IN RATS BY 2-ACETYLAMINOFLUORENE

Abstract

1. Tumors of the external auditory canal region were produced by oral administration of 2-acetylaminofluorene in 71 rats out of 124 which survived a 6 month period of administration of the compound. In 12 animals the tumors were bilateral. Tumors in other locations, such as the liver, breast, etc., were less frequent.