Multideterminant role of calcium in hippocampal synaptic plasticity
- 1 December 1994
- journal article
- review article
- Published by Wiley in Hippocampus
- Vol. 4 (6), 623-634
- https://doi.org/10.1002/hipo.450040602
Abstract
Hippocampal CA1 cells possess several varieties of long‐lasting synaptic plasticity: two different forms of long‐term potentiation (LTP) and at least one form of long‐term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca2+ influx, all can be blocked by Ca2+ chelators, and all activate Ca2+‐dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage‐dependent differences in cytosolic Ca2+ concentration acting upon Ca2+ substrates of differing Ca2+ affinities and compartmentalization of the Ca2+ and its substrates.Keywords
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