Prevalence of diabetes mellitus in odontogenic infections and oral candidiasis: an analysis of neutrophil suppression
- 28 April 1993
- journal article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 22 (4), 168-174
- https://doi.org/10.1111/j.1600-0714.1993.tb01051.x
Abstract
The prevalence of diabetes mellitus (DM) in odontogenic infections and oral candidiasis was examined, and influences of DM on the clinical manifestations of the infections and neutrophil functions were investigated. Among 21 severe and 221 mild odontogenic infections. DM was detected in 5 cases in each group. Of 64 cases of symptomatic oral candidiasis, 8 cases were complicated with DM which was detected by blood examination during treatment. During the period of infection, the mean fasting blood sugar level was 16.0 ± 4.4 and 9.8 ± 1.2 minol/l in the DM‐complicated odontogenic infections and candidiasis, respectively. All white blood counts. C‐reactive protein levels and erythrocyte sedimentation rates were more elevated in DM(+) odontogenic infection cases than in DM(−) ones. In DM(+) candidiasis, hyposalivation (0.79 + 0.54 ml/10 min) was observed. The polymorphonuclear leukocytes from diabetic patients, especially those with candidiasis, produced less free oxygen radicals and exhibited reduced phagocytosis and intracellular killing of Candida cells associated with this reduced O2− generation during the infection. These suppressed neutrophil functions increased after treatment but did not reach control levels. These results indicate that DM is a predisposing condition for odontogenic infections and oral candidiasis, that DM‐complicated infections become severe because of neutrophil suppression, and that examination of blood sugar level should be essential for patients with oral infections.Keywords
This publication has 26 references indexed in Scilit:
- Oral mycoses in HIV infectionOral Surgery, Oral Medicine, Oral Pathology, 1992
- Defective Neutrophil Function in an Insulin‐Dependent Diabetes Mellitus Patient. A Case ReportThe Journal of Periodontology, 1991
- Gustatory impairment and salivary gland pathophysiology in relation to oral cancer treatmentInternational Journal of Oral & Maxillofacial Surgery, 1990
- Oral candidiasis in Sjögren's syndrome: Prevalence, clinical correlations, and treatmentOral Surgery, Oral Medicine, Oral Pathology, 1989
- Oral infections and fever in immunocompromised patients with haematologic malignanciesEuropean Journal of Clinical Microbiology & Infectious Diseases, 1989
- Pernicious anemia with associated glossodyniaThe Journal of the American Dental Association, 1988
- Odontogenic infectionsBritish Dental Journal, 1984
- Infection and diabetes: The case for glucose controlAmerican Journal Of Medicine, 1982
- The effect of secretory immunoglobulin A on the in-vitro adherence of the yeast Candida albicans to human oral epithelial cellsArchives of Oral Biology, 1982
- Blood insulin responses to blood glucose levels in high output sepsis and septic shockThe American Journal of Surgery, 1978