Alternative splicing and evolution
- 17 October 2003
- Vol. 25 (11), 1031-1034
- https://doi.org/10.1002/bies.10371
Abstract
Alternative splicing is a critical post‐transcriptional event leading to an increase in the transcriptome diversity. Recent bioinformatics studies revealed a high frequency of alternative splicing. Although the extent of AS conservation among mammals is still being discussed, it has been argued that major forms of alternatively spliced transcripts are much better conserved than minor forms. 1 It suggests that alternative splicing plays a major role in genome evolution allowing new exons to evolve with less constraint. BioEssays 25:1031–1034, 2003.Keywords
This publication has 26 references indexed in Scilit:
- Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or lossNature Genetics, 2003
- Identification of Alternate Polyadenylation Sites and Analysis of their Tissue Distribution Using EST DataGenome Research, 2001
- Genome-wide detection of alternative splicing in expressed sequences of human genesNucleic Acids Research, 2001
- Gene Structure Prediction and Alternative Splicing Analysis Using Genomically Aligned ESTsGenome Research, 2001
- Initial sequencing and analysis of the human genomeNature, 2001
- EST comparison indicates 38% of human mRNAs contain possible alternative splice formsFEBS Letters, 2000
- ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genomeNature Genetics, 2000
- Frequent Alternative Splicing of Human GenesGenome Research, 1999
- Alternative splicing of human genes: more the rule than the exception?Trends in Genetics, 1999
- Split genes and RNA splicingCell, 1994