Goodman et al.'s method for augmenting the number of nucleotide substitutions
- 1 March 1978
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 11 (1), 67-73
- https://doi.org/10.1007/bf01768026
Abstract
Statistical properties of Goodman et al.'s (1974) method of compensating for undetected nucleotide substitutions in evolution are investigated by using computer simulation. It is found that the method tends to overcompensate when the stochastic error of the number of nucleotide substitutions is large. Furthermore, the estimate of the number of nucleotide substitutions obtained by this method has a large variance. However, in order to see whether this method gives overcompensation when applied together with the maximum parsimony method, a much larger scale of simulation seems to be necessary.Keywords
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