Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.
- 1 September 1985
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 82 (18), 6352-6356
- https://doi.org/10.1073/pnas.82.18.6352
Abstract
The role of inositol 1,4,5-triphosphosphate (InsP3) in excitation-contraction coupling in [Rana catesbeiana] skeletal muscle was investigated by several methods. The following results were obtained. InsP3 is released by electrical stimulation of muscles. Exogenous InsP3 releases calcium from skinned muscle fibers at relatively high doses under normal conditions but does so at very low concentrations when blockers of the InsP3 5-phosphatase are present. Blockers of InsP3 release are effective blockers of calcium transients elicited by electrical stimulation of muscle fibers. It is proposed that InsP3 acts as a chemical second messenger between transverse (T)-tubular membrane depolarization and calcium release from the sarcoplasmic reticulum in skeletal muscle.This publication has 35 references indexed in Scilit:
- Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesteraseNature, 1985
- Muscarinic receptor-induced phosphoinositide hydrolysis at resting cytosolic Ca2+ concentration in PC12 cells.The Journal of cell biology, 1985
- Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liverNature, 1984
- Inositol trisphosphate, a novel second messenger in cellular signal transductionNature, 1984
- Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphateNature, 1983
- Arsenazo III and antipyrylazo III calcium transients in single skeletal muscle fibers.The Journal of general physiology, 1982
- INHIBITION BY NEOMYCIN OF POLYPHOSPHOINOSITIDE TURNOVER IN SUBCELLULAR FRACTIONS OF GUINEA‐PIG CEREBRAL CORTEX IN VITROJournal of Neurochemistry, 1976
- Effects of Potentiators of Muscular Contraction on Binding of Cations by Sarcoplasmic ReticulumThe Journal of general physiology, 1968
- Calcium and muscle contractionProgress in Biophysics and Molecular Biology, 1968
- Thermodynamic Quantities Associated with the Interaction of Adenosine Triphosphate with Metal Ions1,2Journal of the American Chemical Society, 1966