Migration Inhibition of Endothelial Cells by Lymphokine-Containing Supernatants
- 15 January 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 215 (4530), 301-303
- https://doi.org/10.1126/science.6797069
Abstract
Many of the reactions of cellular immunity are mediated by soluble lymphocyte-derived factors (lymphokines). One important category of lymphokine action involves effects on cell motility. These effects have been described mainly with respect to inflammatory cells. In this report, we describe the ability of a lymphocyte product to inhibit the migration of endothelial cells in a system in vitro. The responsible factor is distinct from a previously described mediator that inhibits the migration of tumor cells. The ability of lymphocytes to influence the migration properties of endothelial cells is consistent with data of others showing a relation between the immune system and processes involving neovascularization.This publication has 14 references indexed in Scilit:
- Correlation between agarose microdroplet and capillary tube procedures as assays for migration inhibition of target cellsJournal of Immunological Methods, 1980
- Isolation and Culture of Pulmonary Artery Endothelial CellsTissue and Cell, 1978
- Activated macrophages induce vascular proliferationNature, 1977
- D-valine as a selective agent for normal human and rodent epithelial cells in cultureCell, 1975
- Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction.The Journal of Experimental Medicine, 1975
- Quantitative Aspects of the Migration Inhibition ReactionImmunological Communications, 1973
- ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESISThe Journal of Experimental Medicine, 1971