CHANGES IN THE SEDIMENTATION RATE OF THE ERYTHROCYTES AND IN THE PLASMA PROTEINS FOLLOWING PROLONGED CHLOROFORM ADMINISTRATION TO THE DOG

Abstract

Four dogs were poisoned by prolonged chloroform administration. The resulting liver injury was associated with a marked drop in the plasma fibrinogen and with a greatly reduced sedimentation rate of the erythrocytes, as measured by the Plass-Rourke method using heparin as anticoagulant. Subsequent liver repair was associated with increase in the plasma fibrinogen and sedimentation rate of the erythrocytes. These changes were parallel and apparently dependent. There were no distinct changes in the albumin and globulin contents of the plasma.