Cytogenetic analysis of 688 couples experiencing multiple spontaneous abortions
- 1 March 1988
- journal article
- research article
- Published by Wiley in American Journal of Medical Genetics
- Vol. 29 (3), 549-556
- https://doi.org/10.1002/ajmg.1320290312
Abstract
We report on cytogenetic analysis of 688 couples experiencing two or more first-and/or second-trimester abortions (<20 weeks). The overall abnormality rate was 6.83% (47 couples). However, exclusion of those anomalies not generally accepted as being causal in spontaneous abortion leaves an abnormality rate of only 2.33% (16 couples). We discuss the significance of balanced translations, inversions, sex chromosome aneuploidies, and mosaicisms thereof in the causation of multiple abortions.Keywords
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