A Broncho-Constrictor Factor in Cigarette Smoke

Abstract

Experiments on guinea pigs indicate that cigarette smoke contains a broncho-constrictor agent. The intensity of the bronchoconstrictor response is different with different lengths of cigarettes. Evidence is presented which indicates that the active agent in the smoke is not nicotine. Experiments using 2 brands of filter-tip cigarettes indicated that the filter-tip did not influence the response of the lung to the cigarette smoke. The single brand of denicotinized cigarettes showed significantly less total bronchoconstrictor effect than did the conventional cigarettes.