Lack of Catheter Infection by the efg1 / efg1 cph1 / cph1 Double-Null Mutant, a Candida albicans Strain That Is Defective in Filamentous Growth

Abstract

The molecular controls regulating the successful colonization of Candida albicans on foreign materials are not known. Here we show that a mutant C. albicans strain defective in filamentous growth and lacking the transcription factors Efg1p and Cph1p has a profoundly deficient potential for colonizing on polyurethane catheters.