Action of Cortisone on Disseminated Tumor Cells after Removal of the Primary Growth
- 21 January 1955
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 121 (3134), 100-101
- https://doi.org/10.1126/science.121.3134.100
Abstract
A transplantable carcinoma of the bladder epithelium of a C57 mouse was injected into the tail vein of this strain. After the tumor in the tail reached a diameter of 1 cm. the tail was amputated. After 14-16 days, 40 cortisone-treated mice had a total of 193 metastases in 31 animals, whereas in a control group of 38 animals, only 18 had a total of 56 metastases. These results confirm the view of Pomeroy (Cancer Research, 14, 201 (1954)) that Cortisone stimulates metastases.Keywords
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