Difference in Triptan Effect in Patients With Migraine and Early Allodynia
- 1 October 2008
- journal article
- research article
- Published by SAGE Publications in Cephalalgia
- Vol. 28 (10), 1031-1038
- https://doi.org/10.1111/j.1468-2982.2008.01642.x
Abstract
The aim of this study was to determine whether in migraine patients with and without aura early treatment with various triptans leads to differences in pain reduction after 1 h and in modulating cutaneous allodynia. Thirty-six patients with early manifestation of a clinically recognizable allodynia of the face and non-responders to earlier treatment with sumatriptan 100 mg were included. Patients were randomized to six triptan treatment groups. Significant pain reduction was seen only in the group receiving zolmitriptan nasal spray 5 mg with a mean visual analogue scale (VAS) score of 3.8 (S.D. 1.2) at baseline and 2.4 (S.D. 1.3; P = 0.015) at 1 h after using the triptan and was thus a predictor of a VAS score 3 within 1 h. The study results indicate that migraine headache intensity can be reduced within 1 h by using zolmitriptan 5 mg nasal spray in spite of the presence of early cutaneous allodynia.Keywords
This publication has 14 references indexed in Scilit:
- Can allodynic migraine patients be identified interictally using a questionnaire?Neurology, 2005
- Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptorsPain, 2005
- Defeating migraine pain with triptans: A race against the development of cutaneous allodyniaAnnals of Neurology, 2003
- Analgesic triptan action in an animal model of intracranial pain: A race against the development of central sensitizationAnnals of Neurology, 2003
- Pain-Free Results With Sumatriptan Taken at the First Sign of Migraine Pain: 2 Randomized, Double-Blind, Placebo-Controlled StudiesMayo Clinic Proceedings, 2003
- Within‐Patient Early Versus Delayed Treatment of Migraine Attacks With Almotriptan: The Sooner the BetterHeadache: The Journal of Head and Face Pain, 2002
- Treatment of Mild Headache in Disabled Migraine Sufferers: Results of the Spectrum StudyHeadache: The Journal of Head and Face Pain, 2000
- Effect of early intervention with sumatriptan on migraine pain: Retrospective analyses of data from three clinical trialsClinical Therapeutics, 2000
- The development of cutaneous allodynia during a migraine attack Clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraineBrain, 2000
- An association between migraine and cutaneous allodyniaAnnals of Neurology, 2000