Depletion of Erythrocyte Phosphoribosylpyrophosphate in Man
- 26 November 1970
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 283 (22), 1177-1182
- https://doi.org/10.1056/nejm197011262832201
Abstract
Allopurinol, a potent inhibitor of xanthine oxidase, is widely used for the treatment of hyperuricemia. When this drug was given to nine patients with gout, the concentration of phosphoribosylpyrophosphate (PRPP) in red cells was reduced significantly (p<0.01). Studies in vivo and in vitro showed that this depletion of PRPP results from the enzymatic conversion of allopurinol to allopurinol ribonucleotide, a process that consumes PRPP.Keywords
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