Structure of the type XXXIII Streptococcuspneumoniae (pneumococcal) capsular polysaccharide

Abstract
The type XXXIII S. pneumoniae (pneumococcal) capsular polysaccharide contains D-glucose (2 mol), D-galactose (1 mol), D-glucuronic acid (1 mol) and 2-acetamido-2-deoxy-D-mannose (1 mol). Structural investigations by methylation analysis, specific degradations and NMR spectroscopy showed that the repeating unit was a linear pentasaccharide of the following structure: .fwdarw. 3)-.alpha.-D-Galp-(1 .fwdarw. 3)-.beta.-D-ManpNAc-(1 .fwdarw. 4)-.alpha.-D-Glcp-(1 .fwdarw. 4)-.beta.-D-Glcp-(1 .fwdarw. 4)-.alpha.-D-GlcpA-(1 .fwdarw.