THROMBOLYTIC THERAPY WITH CA-7 (FIBRINOLYTIC ENZYME FROM ASPERGILLUS ORYZAE) IN THE DOG
- 1 September 1965
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 43 (5), 731-740
- https://doi.org/10.1139/y65-075
Abstract
The lysis of occluding arterial thrombi in dogs with intravenous injections of CA-7 (fibrinolytic enzyme from Aspergillus oryzae) is described. The treatments were conducted over a 3-day period and resulted in lysis of 75% of the arterial thrombi. This is compared with the results of an earlier study in which dogs received massive single doses of the enzyme. The therapeutic effectiveness is similar in both series. The 3-day treatment has advantages in reduced toxicity and increased safety.This publication has 5 references indexed in Scilit:
- THE ACTION OF A PROTEOLYTIC ENZYME FROM ASPERGILLUS ORYZAE ON COMPONENTS OF THE BLOOD CLOTTING SYSTEMCanadian Journal of Physiology and Pharmacology, 1964
- Fibrin Suspension Assay for Fibrinolytic ActivityBlood, 1964
- THE EVALUATION IN THE DOG OF A PROTEOLYTIC ENZYME DERIVED FROM ASPERGILLUS ORYZAECanadian Journal of Physiology and Pharmacology, 1964
- HUMAN FIBRINOLYSIN WITH AND WITHOUT UROKINASE: ITS EFFECT ON EXPERIMENTAL ARTERIAL THROMBI IN DOGSCanadian Journal of Biochemistry and Physiology, 1962