THROMBOLYTIC THERAPY WITH CA-7 (FIBRINOLYTIC ENZYME FROM ASPERGILLUS ORYZAE) IN THE DOG

Abstract

The lysis of occluding arterial thrombi in dogs with intravenous injections of CA-7 (fibrinolytic enzyme from Aspergillus oryzae) is described. The treatments were conducted over a 3-day period and resulted in lysis of 75% of the arterial thrombi. This is compared with the results of an earlier study in which dogs received massive single doses of the enzyme. The therapeutic effectiveness is similar in both series. The 3-day treatment has advantages in reduced toxicity and increased safety.