Uterine cervical punch biopsy specimens can be analyzed by 1h mrs
- 1 February 1990
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 13 (2), 324-331
- https://doi.org/10.1002/mrm.1910130216
Abstract
Biopsy specimens of the uterine cervix, including colposcopically directed punch biopsy specimens of females with atypical Papanicolaou smear tests, are suitable for analysis by magnetic resonance (MR) spectroscopy. A narrow lined lipid MR spectrum, characteristic of malignant tissue, is obtained from a 6‐mm3 biopsy specimen of histologically confirmed squamous carcinoma of the cervix. In contrast, specimens containing inflammatory cells generate a broad component only centered at 1.3 ppm with a T2 relaxation value of less than 350 ms. Most biopsy specimens which contain dysplastic cells or evidence of human papilloma virus (HPV) infection have a discernible lipid spectrum similar to that of the malignant tissue specimen. Long T2 relaxation values found in malignant tissue specimens at 1.3 and 1.2 ppm are observed in some but not all of the biopsies which show evidence of HPV infection. The suitability of small tissue samples, such as punch biopsy specimens, for study by MR illustrates the sensitivity of this technique and its potential as an aid to histopathological discrimination between the various precursor states of cervical cancer.This publication has 17 references indexed in Scilit:
- Changing character of cervical cancer in young women.BMJ, 1989
- Invasive squamous cell carcinoma of the cervix in women less than 35 years old: Recurrent versus nonrecurrent diseaseAmerican Journal of Obstetrics and Gynecology, 1988
- Papillomavirus and cervical cancer: A clinical and laboratory studyJournal of Medical Virology, 1988
- Inhibition of metastatic potential by fucosidase: An NMR study identifies a cell surface metastasis markerJournal of Cellular Biochemistry, 1988
- Assignment of methylene proton resonances in NMR spectra of embryonic and transformed cells to plasma membrane triglyceride.Journal of Biological Chemistry, 1986
- CLASSIFICATION OF HUMAN TUMOURS BY HIGH-RESOLUTION MAGNETIC RESONANCE SPECTROSCOPYThe Lancet, 1986
- Assignment of acyl chain resonances from membranes of mammalian cells by two-dimensional NMR methodsBiochemistry, 1984
- NMR methods for characterizing the state of the surfaces of complex mammalian cellsJournal of Biochemical and Biophysical Methods, 1984
- Age and prognosis in stage Ib squamous cell carcinoma of the uterine cervixGynecologic Oncology, 1983
- Homonuclear decoupling and peak elimination in Fourier transform nuclear magnetic resonanceJournal of the American Chemical Society, 1973