Furosemide kinetics and dynamics after kidney transplant

Abstract

Differences between responder (R) (40-80 mg/day) and nonresponder (NR) (.gtoreq. 120 mg/day) patients after kidney transplant were examined with respect to furosemide kinetics and dynamics. Nonresponders had reduced plasma clearance (NR, 64 .+-. 21.4 and R, 105 .+-. 23 ml/min, 2-sample t test; P < 0.05), renal clearance (NR, 18.4 .+-. 8.1 and R, 47.1 .+-. 11.0 ml/min; P < 0.005) and renal clearance to creatinine clearance ratio (NR, 0.43 .+-. 0.15 and R, 0.80 .+-. 0.07 P < 0.005). Half-life rose in the nonresponders (NR, 130 .+-. 13 and R, 87.6 .+-. 16.3 min; P < 0.005). There was no difference between groups with respect to nonrenal clearance, extent of availability, volume of distribution steady state and the fraction of the dose excreted unchanged in the urine after i.v. administration. Apparently nonresponders have less ability to secrete furosemide into tubular fluid and less ability to respond to drug.