The dissolution of commercial aspirin
- 1 January 1969
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 21 (1), 28-34
- https://doi.org/10.1111/j.2042-7158.1969.tb08126.x
Abstract
Two samples of commercial aspirin showing a difference in intrinsic dissolution rate have been studied. Crystallographic examination and solubility determinations failed to reveal any difference between them. The effects of agitation and temperature on intrinsic dissolution rates showed that the samples had different thermodynamic activities and, depending on the conditions, the metastable form was capable of rapid reversion to a more stable form.Keywords
This publication has 13 references indexed in Scilit:
- Aspirin: Dissolution Rates of Two Polymorphic FormsScience, 1968
- The dissolution of aspirin and aspirin tabletsFn fn1Journal of Pharmacy and Pharmacology, 1967
- Diffusional Models Useful in BiopharmaceuticsJournal of Pharmaceutical Sciences, 1967
- Polymorphism and Drug Availability IIJournal of Pharmaceutical Sciences, 1967
- Dissolution Kinetics of Certain Crystalline Forms of Prednisolone IIJournal of Pharmaceutical Sciences, 1965
- Relationship Between In Vitro Dissolution Rates and Solubilities of Numerous Compounds Representative of Various Chemical SpeciesJournal of Pharmaceutical Sciences, 1965
- Dissolution Rate Studies on Methylprednisolone PolymorphsJournal of Pharmaceutical Sciences, 1964
- Loss of Sensitivity in Distinguishing Real Differences in Dissolution Rates Due to Increasing Intensity of AgitationJournal of Pharmaceutical Sciences, 1962
- Transport control in heterogeneous reactionsQuarterly Reviews, Chemical Society, 1952
- The dissolution and diffusion of aspirin in aqueous mediaTransactions of the Faraday Society, 1951