Pharmacokinetic data of propranolol enantiomers in a comparative human study with (S)‐ and (R,S)‐propranolol

Abstract

The pharmacokinetics of (S)‐propranolol were compared after the oral administration of a 40 mg dose of the pure enantiomer and an 80 mg dose of a racemic mixture of (R,S)‐propranolol. The results of this study indicate that the bioavailability of (S)‐propranolol, as expressed by the mean area uner the concentration‐time curve (AUC) and maximum serum concentration, is lower after 40mg of the optically pure drug than after the racemic drug.