Peripheral neuropathy in mutant diabetic mouse [C57BL/Ks (db/db)]
- 1 January 1978
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 41 (2), 85-89
- https://doi.org/10.1007/bf00689757
Abstract
A new animal model for the study of diabetic neuropathy is presented. The homozygote (db/db) of the mouse strain C57BL/Ks shows severe diabetes with longstanding hyperglycemia. Electrophysiological studies showed severely decreased motor nerve conduction velocity. Morphometric examination of sensory and motor nerves at different levels revealed absence of large myelinated fibers, with morphological features indicative of axonal atrophy.Keywords
This publication has 30 references indexed in Scilit:
- Axonal dwindling in early experimental diabetes. I. A study of cross sectioned nervesDiabetologia, 1976
- Segmental demyelination in the distal peripheral nerves of chronically diabetic chinese hamstersDiabetologia, 1974
- Pathology of diabetic neuropathyThe Journal of Pathology, 1971
- Studies in the diabetic mutant mouse: I. Light microscopy and radioautography of pancreatic isletsDiabetologia, 1970
- The effects of hypoxia on the excitability of the isolated peripheral nerves of alloxan-diabetic rats.Journal of Neurology, Neurosurgery & Psychiatry, 1969
- Hypertrophic changes in diabetic neuropathyActa Neuropathologica, 1968
- Pathological changes in the central and peripheral nervous system of young long-term diabeticsDiabetologia, 1968
- Studies with the mutation, diabetes, in the mouseDiabetologia, 1967
- SCHWANN-CELL ABNORMALITIES IN DIABETIC NEUROPATHYThe Lancet, 1965
- Nerve Conduction Changes in Experimental Diabetes*JCI Insight, 1964