Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action
Open Access
- 1 February 2005
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 55 (2), 135-138
- https://doi.org/10.1093/jac/dkh530
Abstract
Pyridine N-oxide derivatives represent a new class of anti-HIV compounds, for which some members exclusively act through inhibition of HIV-1 reverse transcriptase and thus characteristically behave as non-nucleoside reverse transcriptase inhibitors. Other members act, additionally or alternatively, at a post-integrational event in the replication cycle of HIV, that is, at the level of HIV gene expression. Repeated administration of one of the prototype compounds (JPL-32) to DBA/2 and hu-PBMC-SCID mice demonstrated, in the absence of any acute toxicity, protective activity against HIV-induced destruction of CD4 human T lymphocytes.Keywords
This publication has 2 references indexed in Scilit:
- Novel Human Immunodeficiency Virus (HIV) Inhibitors That Have a Dual Mode of Anti-HIV ActionAntimicrobial Agents and Chemotherapy, 2003
- Inhibition of Human Immunodeficiency Virus by a New Class of Pyridine Oxide DerivativesAntimicrobial Agents and Chemotherapy, 2003