OVERLAP STIMULATION OF PRIMARY AND SECONDARY B CELLS BY CROSS-REACTING DETERMINANTS
Open Access
- 1 November 1973
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 138 (5), 1276-1281
- https://doi.org/10.1084/jem.138.5.1276
Abstract
Experiments were carried out to test the validity of the hypothesis that postulated differences in the nature of the antigen receptors of primary and secondary B cells should be reflected in a greater specificity in primary B-cell stimulation (2). Enumeration of clonal precursors stimulated by either DNP-Hy, TNP-Hy, or a mixture of both antigens confirmed this hypothesis. Since the sum of primary B cells stimulated by DNP-Hy and TNP-Hy is approximately equal to the number stimulated by a mixture of both, overlap stimulation of primary B cells by these antigens could be considered negligible. In contrast, the stimulation of B cells from mice previously immunized with DNP-Hy showed extensive overlap of stimulation by DNP-Hy and TNP-Hy. Thus secondary B cells appear less fastidious in their affinity requirements for stimulation than primary B cells.Keywords
This publication has 11 references indexed in Scilit:
- MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODYThe Journal of Experimental Medicine, 1973
- Original antigenic sin at the cellular level. II. Specificity of the antibodies produced by individual cellsEuropean Journal of Immunology, 1973
- INITIATION OF ANTIBODY RESPONSES BY DIFFERENT CLASSES OF LYMPHOCYTESThe Journal of Experimental Medicine, 1972
- THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLSThe Journal of Experimental Medicine, 1972
- Regain of homogeneous binding activity after recombination of chains of "mono- focal" antibody.1971
- Antibody with homogeneous antigen binding produced by splenic foci in organ cultureImmunochemistry, 1969
- Degeneracy in the secondary immune response: stimulation of antibody formation by cross-reacting antigens.1969
- General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice.1969
- DISQUISITIONS ON ORIGINAL ANTIGENIC SINThe Journal of Experimental Medicine, 1966
- Anti-Bovine Serum Albumin Specificity and Binding Affinity after Termination of Tolerance to Bovine Serum AlbuminThe Journal of Immunology, 1965