ACTION OF ESTRONE AND PROGESTERONE ON NUCLEAR VOLUME (STUDIED BY APPLYING THE KARYOMETRIC-STATISTICAL METHOD)

Abstract

Adult female rats were ovariectomized and a month later were given one of the following daily treatments-(1) 100 I. U. of estrone for 3 days, (2) 250 I. U. of estrone for 4 days, (3) 0.5 mg. of progesterone for 2 days, (4) 0.5 mg. of progesterone for 4 days or served as (5) untreated controls. All were autopsied 6 hrs. after the last injn. In sections of each uterine endometrium the volume of 150 nuclei was detd. Estrone doubled nuclear volume thus inducing interphasic nuclear growth. Progesterone had no effect.