The Role of Cerebral Perfusion Pressure as Origin of Brain Edema in Acute Arterial Hypertension

Abstract

In 8 cats, cerebral perfusion pressure (CPP) was evaluated over a period of 5 min after production of an acute arterial hypertension. The mean increase of blood pressure, CPP and ICP [intracranial pressure] was 100%. The fact that ICP did not play any role in acute hypertension indicated that an abrupt elevation of filtration pressure within the capillaries must be the decisive factor leading to edema.