The mechanism of immunological unresponsiveness to picryl chloride and the possible role of antibody mediated depression.

Abstract

Mice were rendered specifically unresponsive to picryl chloride by pretreatment with picryl sulphonic acid. These mice fail to develop contact sensitivity, as judged by increment of ear thickness, when subsequently sensitized on the abdomen and challenged 6 days later with picryl chloride on the ear.